BPC-157 in people: every study and trial, counted

Tested in people 6 published reports, 118 people enrolled. 4 registered trials, 0 with results. Last checked .

Published reports, oldest first
YearStudy and designPeopleWhat happened
2002 to 2003 Safety and blood levels of an enema form in healthy volunteersRandomized, placebo-controlled phase 1 32Healthy men; 24 got BPC-157 Most blood samples held too little BPC-157 to measure. The study tested safety, not benefit.
2005 Two-week enema trial in mild to moderate ulcerative colitisRandomized, double-blind, placebo-controlled 53Adults with mild to moderate ulcerative colitis Disease activity fell 3.2 points on BPC-157 and 1.6 on placebo. The gap between groups was not statistically clear (95% CI -4.84 to 1.62).
2021 Knee injections reviewed from charts, with a phone surveyRetrospective chart review, no control group 16Adults with knee pain at one clinic 11 of the 12 who had BPC-157 alone said their knee pain improved a lot; 3 of the 4 on the combination did. No standard pain or function scale was used.
2024 Bladder-wall injections for interstitial cystitisSingle group, no control 12Women aged 39 to 76 whose interstitial cystitis had not responded to pentosan polysulfate 10 of 12 reported their symptoms fully gone after one procedure; the other 2 rated their improvement at 80%.
2025 Two days of IV infusions in healthy adultsSingle group, no control 2A 58-year-old man and a 68-year-old woman who had used IV BPC-157 before No measurable change in heart, liver, kidney, thyroid or blood sugar markers over three days.
2026 Three dental patients with a numb lip and chin after surgeryCase report, no control 3Three patients with lower-jaw nerve injury after implant or extraction surgery Feeling came back almost fully in all three after a four-week course of injections near the nerve. The authors write that natural recovery cannot be ruled out and the cases do not show cause.
Registered trials on ClinicalTrials.gov
TrialWhat it testsPeopleStatus
NCT02637284 PCO-02: oral tablet safety and blood-level studyPhase 1. Randomized, placebo-controlled, healthy volunteers. 42planned UnknownResults: none posted, and FDA found no published paper
NCT07752381 BPC-157 gummies and markers of inflammationNot applicable (dietary supplement). Single group, no control, sponsored by the gummy maker. 40enrolled CompletedResults: none posted
NCT07437547 BPC 157 for acute hamstring strainPhase 2. Randomized, quadruple-blind, placebo-controlled. 120planned RecruitingResults: not due yet
NCT07803250 BPC-157 after rotator cuff repair surgeryPhase 1. Randomized pilot; control arm listed as sham (no treatment). 30planned Not yet recruitingResults: not due yet