Glutathione

Peptide studied for antioxidant defense, skin brightening, detoxification support. How it works, the dose and timing studied, what it interacts with, and the research behind the grade.

Grade C evidence early: mostly mechanism or small studies Also known as Liposomal glutathione
All compounds
Best for Antioxidant defense, Skin brightening, Detoxification support
Typical dose 250–500 mg daily (liposomal or S-acetyl forms)
Timing On an empty stomach
Category Peptide
What are peptides? Glutathione is a three-amino-acid peptide your cells make. The guide explains how peptides differ from proteins and drugs, and why most therapeutic ones are injected.
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What it is and the mechanism

A tripeptide of glutamate, cysteine, and glycine that is the cell’s primary antioxidant and a key player in phase II detoxification. Oral bioavailability is debated; liposomal and acetylated forms aim to improve absorption.

When and how much to take

The dose below reflects the range used in published research. Match the form alongside the milligrams. Set your own wake and bed times to map the timing onto your day.

When to take Glutathione

Dose: 250–500 mg daily (liposomal or S-acetyl forms). Set your own wake and bed times to map the guidance onto your day.

12a6a12p6pDAY1 dose
12 pmAnytime. Timing is flexible. Pick a slot you can keep consistent.

These statements have not been evaluated by the Food and Drug Administration. This information is not intended to diagnose, treat, cure, or prevent any disease.

Interactions and cautions

Read these before combining this with other supplements or medication. The risk is rarely the headline, it is the interaction you did not check.

Interactions
  • Chemotherapy, may interact; consult an oncologist
Cautions
  • Oral absorption is limited; NAC may raise glutathione more reliably
  • Generally well tolerated

What pairs well, and what to keep apart

Derived from shared topics, complementary categories, and the interaction list. Introduce one compound at a time so you can tell what works.

Keep apart from

No direct compound conflicts derived. Still check the interactions list above against your medication.

Compounds in the same topics

Often considered alongside this one. Each carries its own evidence grade.

More compounds for longevity & aging

Other compounds studied for longevity & aging, strongest human evidence first.