Melatonin

Other studied for circadian phase shift, jet lag, sleep onset latency. How it works, the dose and timing studied, what it interacts with, and the research behind the grade.

Grade A evidence strong: trials and meta-analyses agree
All compounds
Best for Circadian phase shift, Jet lag, Sleep onset latency
Typical dose 0.3–1 mg for circadian signaling; up to 3 mg for jet lag
Timing 30–90 minutes before target bedtime; timing matters more than dose
Category Other
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What it is and the mechanism

Endogenous hormone produced by the pineal gland in response to darkness that signals circadian timing to peripheral clocks. Exogenous supplementation is most effective as a chronobiotic (timing agent) at low doses rather than a sedative.

When and how much to take

The dose below reflects the range used in published research. Match the form alongside the milligrams. Set your own wake and bed times to map the timing onto your day.

When to take Melatonin

Dose: 0.3–1 mg for circadian signaling; up to 3 mg for jet lag. Set your own wake and bed times to map the guidance onto your day.

12a6a12p6pDAY1 dose
12 pmAnytime. Timing is flexible. Pick a slot you can keep consistent.

These statements have not been evaluated by the Food and Drug Administration. This information is not intended to diagnose, treat, cure, or prevent any disease.

Interactions and cautions

Read these before combining this with other supplements or medication. The risk is rarely the headline, it is the interaction you did not check.

Interactions
  • Anticoagulants (warfarin), may increase bleeding risk
  • CNS depressants, additive sedation
Cautions
  • Higher OTC doses (5–10 mg) are likely supraphysiologic and not more effective
  • Not recommended for long-term nightly use without physician guidance
  • Pediatric use, consult a physician

What pairs well, and what to keep apart

Derived from shared topics, complementary categories, and the interaction list. Introduce one compound at a time so you can tell what works.

Keep apart from

No direct compound conflicts derived. Still check the interactions list above against your medication.

Compounds in the same topics

Often considered alongside this one. Each carries its own evidence grade.

More compounds for sleep & recovery

Other compounds studied for sleep & recovery, strongest human evidence first.