Saffron

Herb studied for mood support, pms comfort, appetite regulation. How it works, the dose and timing studied, what it interacts with, and the research behind the grade.

Grade B evidence moderate: promising but smaller or mixed human trials Also known as Crocus sativus
All compounds
Best for Mood support, PMS comfort, Appetite regulation
Typical dose 28–30 mg standardized extract daily
Timing Split, morning and evening
Category Herb
The daily email

Peptide news each morning, with the study linked

New trials, FDA changes and side-effect reports, written in plain English. Every result says whether it was tested in people or in animals.

Free. One email a morning. Unsubscribe in one click.

What it is and the mechanism

Crocin and safranal modulate serotonin reuptake and have antioxidant activity. Multiple trials show saffron supports mood and premenstrual symptoms, with effect sizes comparable to low-dose interventions.

When and how much to take

The dose below reflects the range used in published research. Match the form alongside the milligrams. Set your own wake and bed times to map the timing onto your day.

When to take Saffron

Dose: 28–30 mg standardized extract daily. Set your own wake and bed times to map the guidance onto your day.

12a6a12p6pDAY2 doses
7 amMorning dose. Take the first portion after waking.
9 pmEvening dose. Take the second portion in the evening.

These statements have not been evaluated by the Food and Drug Administration. This information is not intended to diagnose, treat, cure, or prevent any disease.

Interactions and cautions

Read these before combining this with other supplements or medication. The risk is rarely the headline, it is the interaction you did not check.

Interactions
  • Antidepressants, theoretical serotonergic additive effect
  • Anticoagulants, possible additive effect
Cautions
  • High doses (>1.5 g) can be toxic; stay within supplement ranges
  • Pregnancy, avoid

What pairs well, and what to keep apart

Derived from shared topics, complementary categories, and the interaction list. Introduce one compound at a time so you can tell what works.

Keep apart from

No direct compound conflicts derived. Still check the interactions list above against your medication.

Compounds in the same topics

Often considered alongside this one. Each carries its own evidence grade.

More compounds for focus & mind

Other compounds studied for focus & mind, strongest human evidence first.