Pycnogenol

Other studied for skin and vascular support, blood flow, antioxidant defense. How it works, the dose and timing studied, what it interacts with, and the research behind the grade.

Grade B evidence moderate: promising but smaller or mixed human trials Also known as French maritime pine bark extract
All compounds
Best for Skin and vascular support, Blood flow, Antioxidant defense
Typical dose 50–150 mg daily
Timing With food, often split
Category Other
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What it is and the mechanism

A standardized pine bark extract rich in procyanidins that support nitric oxide-mediated vasodilation, have antioxidant activity, and may improve skin elasticity and microcirculation.

When and how much to take

The dose below reflects the range used in published research. Match the form alongside the milligrams. Set your own wake and bed times to map the timing onto your day.

When to take Pycnogenol

Dose: 50–150 mg daily. Set your own wake and bed times to map the guidance onto your day.

12a6a12p6pDAY2 doses
7 amMorning dose. Take the first portion after waking.
9 pmEvening dose. Take the second portion in the evening.

These statements have not been evaluated by the Food and Drug Administration. This information is not intended to diagnose, treat, cure, or prevent any disease.

Interactions and cautions

Read these before combining this with other supplements or medication. The risk is rarely the headline, it is the interaction you did not check.

Interactions
  • Anticoagulants, possible additive effect
  • Blood pressure and diabetes medications, monitor
Cautions
  • Generally well tolerated; mild GI upset
  • Stop before surgery

What pairs well, and what to keep apart

Derived from shared topics, complementary categories, and the interaction list. Introduce one compound at a time so you can tell what works.

Keep apart from

No direct compound conflicts derived. Still check the interactions list above against your medication.

Compounds in the same topics

Often considered alongside this one. Each carries its own evidence grade.

More compounds for beauty & skin

Other compounds studied for beauty & skin, strongest human evidence first.