Valerian root

Herb studied for sleep latency, sleep quality, anxiety. How it works, the dose and timing studied, what it interacts with, and the research behind the grade.

Grade C evidence early: mostly mechanism or small studies Also known as Valeriana officinalis
All compounds
Best for Sleep latency, Sleep quality, Anxiety
Typical dose 300–600 mg standardized root extract
Timing 30–60 minutes before bed; some evidence for 2-week cumulative benefit
Category Herb
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What it is and the mechanism

Valerenic acid inhibits GABA transaminase (increasing GABA levels) and may have partial agonism at GABA-A receptors. Isovaleric acid contributes to the characteristic odor. Systematic reviews show inconsistent outcomes.

When and how much to take

The dose below reflects the range used in published research. Match the form alongside the milligrams. Set your own wake and bed times to map the timing onto your day.

When to take Valerian root

Dose: 300–600 mg standardized root extract. Set your own wake and bed times to map the guidance onto your day.

12a6a12p6pDAY1 dose
10 pmBefore bed. Take roughly 30 to 60 minutes before lights out.

These statements have not been evaluated by the Food and Drug Administration. This information is not intended to diagnose, treat, cure, or prevent any disease.

Interactions and cautions

Read these before combining this with other supplements or medication. The risk is rarely the headline, it is the interaction you did not check.

Interactions
  • CNS depressants, additive sedation
  • CYP3A4 substrates
Cautions
  • Paradoxical stimulation reported in some individuals
  • Discontinue gradually after prolonged use

What pairs well, and what to keep apart

Derived from shared topics, complementary categories, and the interaction list. Introduce one compound at a time so you can tell what works.

Keep apart from

No direct compound conflicts derived. Still check the interactions list above against your medication.

Compounds in the same topics

Often considered alongside this one. Each carries its own evidence grade.

More compounds for sleep & recovery

Other compounds studied for sleep & recovery, strongest human evidence first.